Cefazolin pharmacokinetics in premature infants
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of isoniazid in low-birth-weight and premature infants.
Isoniazid (INH) is recommended for use as posttuberculosis exposure preventive therapy in children. However, no pharmacokinetic data are available for INH treatment in low-birth-weight (LBW) infants, who undergo substantial developmental and physiological changes. Our objectives in this study were to determine the pharmacokinetic parameters of INH at a dose of 10 mg/kg of body weight/day and to...
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Aztreonam (30 mg/kg of body weight) was administered intravenously over 3 min every 12 h to 30 preterm neonates divided into two groups according to gestational age (mean age for group A was less than 30 weeks and mean age for group B was greater than 30 weeks) and birth weight (mean weight for group A was less than 1,500 g and mean weight for group B was greater than 1,500 g). Blood and urine ...
متن کاملZidovudine pharmacokinetics in premature infants exposed to human immunodeficiency virus.
We used population analysis techniques to determine zidovudine (ZDV) pharmacokinetic parameters in 15 preterm neonates (mean gestational age, 29.4 weeks; mean birth weight, 1,230 g) at a mean age of 5.5 days. The values of the pharmacokinetic parameters were as follows: clearance, 2.53 +/- 0.44 ml/min/kg; volume of distribution, 1.59 +/- 0.51 liters/kg; and half-life, 7.2 +/- 1.5 h. For seven i...
متن کاملMicafungin in Premature and Non-premature Infants
BACKGROUND Invasive fungal infections cause excessive morbidity and mortality in premature neonates and severely ill infants. METHODS Safety and efficacy outcomes of micafungin were compared between prematurely and non-prematurely born infants <2 years of age. Data were obtained from all completed phase I-III clinical trials with micafungin that had enrolled infants (<2 years of age) that wer...
متن کاملPharmacokinetics of intravitreal carbenicillin, cefazolin, and gentamicin in rhesus monkeys.
Although intravitreal injection of antibiotics is being used more widely in treatment of bacterial endophthalmitis, the pharmacokinetic principles that underlie such therapy have been derived exclusively from experiments in the rabbit. Therefore, we studied several representative antibiotics in normal eyes of rhesus monkeys. Carbenicillin (1,000 micrograms), cefazolin (1,000 micrograms), or gen...
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ژورنال
عنوان ژورنال: Journal of Perinatology
سال: 2019
ISSN: 0743-8346,1476-5543
DOI: 10.1038/s41372-019-0368-z